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however, in some extracellular spaces such as the lining fluid of the lung, a thin layer of fluid covering the air spaces where gas exchange occurs, there is high concentration of GSH that is secreted by epithelial cells (Sutherland et al., 1985
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274,275 This, in turn, diminishes additional downstream effects, including oxidative stress, the secretion of pro-degradative substances, modifications to cell phenotype (hypertrophy, M1/M2 macrophage phenotype, fibrosis), and damage or deterioration of joint cells (apoptosis, senescence)